Can you obtain a wholesale dealer's license with your home as your office?

Current law for most states says that you have a physical address as your business address in an area that is zoned and approved by the state for such use.

Different states have different regulations on how to qualify for a dealers license. So its a good idea to check with your local DMV to check. But generally speaking once you have a license from any state then that license is good anywhere in the states.