Yes you can but that is a temporary fix. Some stop leak brands do more damage than good by plugging up everything else like the radiator for example. I recommend "Barr's" brand stop leak if you are going to use one.
Those "fumes" are more than likely coolant steam coming from a leaky heater core. Replacing the heater core is your best option.
Could be, Stuck open thermostat, Low on coolant, Plugged heater core, Temperature blend door actuator malfunction.
The thermostat might need to be replaced. or the coolant level mite be low. it is a sign that it is. and also the type of coolant used if not flushed and replaced tends to clog the heater core. try flushing it out. lastly you have a bad intake gasket and leaking coolant out. 4.3's are notorious for this.
GOOGLE!
They did'NT make the Trailblazer in 2000 might you be looking for information for a 2000 Blazer.
Heater Airbound? Heater control cable not working? Heater core plugged?
If you are standing in front of the truck with the hood up, it is in the back left corner to the right of the heater resistor.
Check the coolant level. My 2000 Ford Taurus has a constant flow cooling system and the heater will not work if the coolant level is too low.
Usually on the coolant outlet just before the upper radiator hose.
Check the coolant system to make sure you are not low. An air bubble going through the heater core can make an odd sound.
if the thermostat is not closing its not letting the coolant get warm enough to heat your vehicle. If it stays open the coolant just keeps circulating and not heating up.
No it will not, it will just back flush the heater core and clean it out.