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You sure enough can. In fact, this morning I took 30mg vyvanse(roughly 12.5 mg Adderall) and 9 and a half hours later I took 37.5 mg hydrocodone. Im feeling good on the hydros right now. Even though adderall is CNS stimulate and hydrocodone is a CNS depressant, they each work in a different way and on different receptors so there is no harm with taking them together or hours apart.

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11y ago
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14y ago

Of course, Hydrocodone as synthetic mix of the opioid codeine and thebaine, it's certainly a painkiller and depressant.

As Adderall is amphetamine - 8-9 hours later the effect will be pretty much gone, if you haven't consumed more.

Taking Hydrocodone, diazepam, morphine, codeine, cannabis, any of those will just cap the effect of the amphetamine rush.

HOWEVER: Do NOT mix these two drugs (upper: amphetamine. Downer: hydrocodone) this may result a change in your heart beat (rare causes, but it has happened). John Belusi died of this, in a sort of similar way; he did a "speedball", it's a cut mix of heroin and cocaine, usually snorted.

Cocaine speeds your heart up, the heroin slows it doing, changing heart beats, as well as obtaining extremely high blood pressure.

Be careful, do not mix it together simontanously, however, 8-9 hours later should be no problem for your body to handle.

Please be careful.

Meryl Linder, Norway.

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14y ago

Sure.. but it sounds like you are abusing them, and not using them for therapeutic intentions mandated by law. =X

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13y ago

no its not totally safe but you'll probably be fine taking them together

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11y ago

Dosage of each would be a factor, but I dont think there would be any contraindication between those two medications.

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Q: Can you take Adderall 20mg then 8-9 hours later take Hydrocodone?
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Can Adderall affect hydrocodone?

Adderall contains amphetamines which are stimulants and hydrocodone are opiates which are considered depressants. If your using it medically then there's no problems, if you want to get high though I'd be careful. I personally used 20mg of snorted adderall and ate 20mg of hydrocodone and had a very nice time. So yes to answer the question it can effect hydrocodone.


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