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First you need to check your hydrocodone medication to see if it already contains aspirin (acetylsalicylic acid or ASA).Hydrocodone is almost always dispensed as a tablet with either a dose of ASA (aspirin) or a dose of APAP (acetaminophen) included. If your hydrocodone tablet already contains aspirin, then you don't want to take any additional aspirin. You could take a dose of acetaminophen with it, but it probably wouldn't offer any additional benefit. If your hydrocodone is compounded with APAP, then you can take aspirin with it. The hydrocodone/APAP compound manages pain and fever, while the aspirin adds the benefit of reducing inflammation somewhat.

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Q: Can you take alleve hydromorphone and aspirin together?
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