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No. The model 25 came in various calibres - we'll assume yours is chambered in either .222 or .223 Remington. The 5.56 does not match dimensions with the .222, so if that's yours, it won't even chamber.

The 5.56 does match dimensions with the .223 Remington. However, there are differences in neck angles which can cause improper headspacing if a 5.56 is run through a dedicated .223 chamber, as well as chamber pressures which may exceed what a .223 rifle is intended to cope with.

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12y ago
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Q: Can you use 5.56 ammo in Savage model 25?
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