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Yes. Many scholars suggest he suffered from Porphyria. A hereditary blood disease that attacks and limits the ability of the neurons. However, it is difficult to be absolutely sure whathe actually had because medical sciences were strictly limited by their knowledge at the time. His behavior during his reign as king was enough for people to realize this without having to really understand the medical details. He was clearly deranged from many different, unrelated historical accounts.

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Q: Did King George III have mental problems?
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