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Not sure, but it sure killed a lot of Native Peoples, as similar outbreaks in 1715 & 1755 did in what is now So. Africa. From Wikipedia: "Edward Anthony Jenner, FRS (17 May 1749 - 26 January 1823) was an English physician and scientist from Berkeley, Gloucestershire, who was the pioneer of smallpox vaccine.[1] He is often called "the father of immunology", and his work is said to have "saved more lives than the work of any other man".

Immunology is what I think best fits the question's "modern medicine". A full answer has to include, at least, Pasteur (rabies vaccine, bacterial role in infection), Lord Lister and Semmelweiss ("Hey, Docs, sterilize your hands between patient exams!" Now again an admonition for doctors, nurses, and, as I have just learned, whole body disinfection prior to surgery that will breach the skin, for patients.

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Q: Did the North American smallpox outbreak of 1775 change modern medicine?
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