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Very good question. As a graduate student studying hematopoietic tumorigenesis, I ask myself the same question daily. Ultimately I don't seem a difference as the term are strictly defined, though it appears that many bioloist use self-renewal when they refer to cells that not only exhibit proliferation potential but whose progency have the potential to develop into more than one lineage. Contrast a proliferating ES cell vs a proliferating Monocyte. But then again, I could see holes in that distinction as well.

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Q: Difference between self-renewal and proliferation
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