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Some antibiotics may cause false positives for opiates:

"A total of 13 quinolone antibiotics were solubilized to represent expected urinary concentrations for testing via 5 different commercial immonoassays (levofloxacin [levaquin], ofloxacin [floxin], gatifloxacin, enoxacin, moxifloxacin, sparfloxacin, pefloxacin, trovafloxacin, lomefloxacin, ciprofloxacin [cipro], cinafloxacin, norfloxacin, and nalidixic acid. The assays included EMIT II reagents, AxSYM flourescence polarization immunoassay, CEDIA, Roche Abuscreen OnLine reagents, and Beckman opiate reagents. In vitro testing against a positive concentration of morphine (300 ng/mL) revealed that 9 of the quinolones (levofloxacin, ofloxacin, perfloxacin, enoxacin, gatifloxacin, lomefloxacin, moxifloxacin, ciprofloxacin, and norfloxacin) caused false positives in at least one of the assay systems. The quinolones that cross reacted most often included levofloxacin (4/5), ofloxacin (4/5), perfloxacin (3/5) and enoxacin (2/5)."

Baden LR Horowitz B, Jacoby H Eliopoulos GM Quinolones and false positive urine screeing for opiates by immunoassay technology JAMA 2001; 286:3115-3119.

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Q: Does Levaquin make a drug screen test positive?
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Levaquin is an antibiotic. Just tell the lab tech that you have recently taken it and they should be able to rule it out of the screening. If you do not inform them, it could potentially show as a false positive for opiates. This is from Levaquins web site: "Some quinolones, including levofloxacin, may produce false-positive urine screening results for opiates using commercially available immunoassay kits. Confirmation of positive opiate screens by more specific methods may be necessary."


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