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There are 2 basic starting points: a newly discovered natural antibiotic (typically excreted by a fungus or a plant) or an existing antibiotic. In the first case the process starts by figuring out how to produce it in quantity and purify it. In the second case an organic chemist studies the structure of the antibiotic and proposes a list of possible chemical changes that might improve its effect or reduce side effects. In both cases a series of tests begin both in vitro and in vivo to make sure it is safe and effective.

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Q: How are new antibiotics developed and tested?
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