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The COOH group can be changed to a tetrazole group to increase the drug's lipophilicity. Both groups have a similar pKa value so the ionisation of the molecules should be similar.
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What are some trends for drugs in a homologous series?
Some trends for drugs in a homologous series include increasing molecular weight and size with an increase in the number of carbon atoms in the chain. This can affect the drug's potency, pharmacokinetics, and metabolic stability. Additionally, there may be trends in solubility, lipophilicity, and protein binding affinity as the alkyl chain length varies.
Can lipophilicity increase toxicity?
Yes. When substances are lipophilic (hydrophobic), they are usually much more easily retained in fat in the body, reducing its elimination rate. This allows for such substances (such as lipophilic vitamins) to accumulate in the body to toxic levels.
Why are lipophilic viruses easier to kill?
Lipophilic viruses require the lipid (fatty) envelope to remain active ("live"*), and the fatty layer can be destroyed by alcohol. Non-lipophilic viruses do not require this fatty envelope, and the protein layer (capsid) is more resistant to alcohol. *Note: viruses are not actually alive, they are only genetic codes with 1 or 2 (lipophilic) protective layers. Biologists call "live" viruses *active* and "dead" viruses *inactive* or *inactivated*.
Is glycine more likely to lose the OH proton or an NH3 plus proton?
It will lose the -OH proton from the -COOH group readily.
The formula of glycine?
C2H5NO2, or more exactly, H2N-CH2-COOH
Why is drug metabolism needed?
Drug metabolism is needed is lipophilic drugs cannot be cleared renally. These lipophilic drugs need to be metabolised into more polar products so that they can be excreted in the urine.
What are polar drugs and non polar drugs?
The process of metabolism transforms lipophilic drugs into more polar(hydrophilic), readily excretable products.
What are some trends for drugs in a homologous series?
Some trends for drugs in a homologous series include increasing molecular weight and size with an increase in the number of carbon atoms in the chain. This can affect the drug's potency, pharmacokinetics, and metabolic stability. Additionally, there may be trends in solubility, lipophilicity, and protein binding affinity as the alkyl chain length varies.
Is an ionized drug more lipophilic or less lipophilic?
An unionized drug tends to be lipophilic (and hence, would be hydrophobic). Thus, an ionized drug on the other hand would be lipophobic (i.e. the opposite of lipophilic), lipid-hating.
Can lipophilicity increase toxicity?
Yes. When substances are lipophilic (hydrophobic), they are usually much more easily retained in fat in the body, reducing its elimination rate. This allows for such substances (such as lipophilic vitamins) to accumulate in the body to toxic levels.
Is a steroid hydrophobic or hydrophilic or amphipathic?
Yes. However, more to the point is that steroid hormones are lipophilic.
Why are lipophilic viruses easier to kill?
Lipophilic viruses require the lipid (fatty) envelope to remain active ("live"*), and the fatty layer can be destroyed by alcohol. Non-lipophilic viruses do not require this fatty envelope, and the protein layer (capsid) is more resistant to alcohol. *Note: viruses are not actually alive, they are only genetic codes with 1 or 2 (lipophilic) protective layers. Biologists call "live" viruses *active* and "dead" viruses *inactive* or *inactivated*.
Why did he write Cat in the Hat?
he was on drugs, literally. the drugs made him more creative, and i guess he liked cats.
Drugs that are formed from other drugs are called?
Ecstasy can be made of a variety of drugs including heroin. To be more exact, drugs that are formed from other drugs are called derivatives.
Does Valium cross the blood brain barrier?
Yes. Valium (diazepam) does indeed cross the blood brain barrier. It is one of the more lipophilic of the benzodiazepine medications.
Are there more illegal drugs than legal drugs in the United states?
In terms of the number of different drugs that are available, there are vastly more legal drugs than illegal drugs. I would also say that legal drugs are used more frequently and by more people than illegal drugs are.
Will more series of friends be made?
no because the actors are getting old and mathew perry(chandler) was on drugs
