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The DIFFERENCE ?!

I think you mean distinguish an acid from a base, which needs an indicator, like red cabbage solution(turns yellowish with acid, darker with base)

Phenolphtaline(Turns violet with a base)

Red/Blue litmus paper(RLP turns blue with a base, and BLP turns red with an acid)

and finally a pH meter/paper.

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Q: How can you safely determine the difference between an acid or a base?
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