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On the afternoon of June 10 - 11, 323 BC, Alexander died of a mysterious illness in the palace of Nebuchadrezzar II of Babylon. He was just one month shy of attaining 33 years of age. Various theories have been proposed for the cause of his death which include poisoning by the sons of Antipater or others, sickness that followed a drinking party, or a relapse of the malaria he had contracted in 336 BC.

It is known that on May 29, Alexander participated in a banquet organized by his friend Medius of Larissa. After some heavy drinking, immediately before or after a bath, he was forced into bed due to severe illness. The rumors of his illness circulated with the troops causing them to be more and more anxious. On June 9, the generals decided to let the soldiers see their king alive one last time. They were admitted to his presence one at a time. While the king was too ill to speak, confined himself to move his hand. The day after, Alexander was dead.

The poisoning theory derives from the story held in antiquity by Justin and Curtius. The original story stated that Cassander, son of Antipater, viceroy of Greece, brought the poison to Alexander in Babylon in a mule's hoof, and that Alexander's royal cupbearer, Iollas, brother of Cassander, administered it. Many had powerful motivations for seeing Alexander gone, and were none the worse for it after his death. Deadly agents that could have killed Alexander in one or more doses include hellebore and strychnine. In R. Lane Fox's opinion, the strongest argument against the poison theory is the fact that twelve days had passed between the start of his illness and his death and in the ancient world, such long-acting poisons were probably not available.

However, the warrior culture of Macedon favoured the sword over strychnine, and many ancient historians, like Plutarch and Arrian, maintained that Alexander was not poisoned, but died of natural causes. Instead, it is likely that Alexander died of malaria or typhoid fever, which were rampant in ancient Babylon. Other illnesses could have also been the culprit, including acute pancreatitis or the West Nile virus. Recently, theories have been advanced stating that Alexander may have died from the treatment not the disease. Hellebore, believed to have been widely used as a medicine at the time but deadly in large doses, may have been overused by the impatient king to speed his recovery, with deadly results. Disease-related theories often cite the fact that Alexander's health had fallen to dangerously low levels after years of heavy drinking and suffering several appalling wounds (including one in India that nearly claimed his life), and that it was only a matter of time before one sickness or another finally killed him.

No story is conclusive. Alexander's death has been reinterpreted many times over the centuries, and each generation offers a new take on it. What is certain is that Alexander died of a high fever on June 10 or 11 of 323 BC.

On his death bed, his marshals asked him to whom he bequeathed his kingdom. Since Alexander had no heir (his son Alexander IV would be born after his death), it was a question of vital importance. There is some debate to what Alexander replied. Some believe that Alexander said, "To the strongest!". It should be taken into note however that he might have said, "To Craterus". This is possible because the Greek pronunciation of "the strongest" and "Craterus" is different only by accent. The phrase and name are in fact, separated by only one letter in the ancient Greek language. Most scholar's believe that if Alexander did intend to choose one of his generals, his obvious choice would've been Craterus because he was the commander of the largest part of the army (infantry), because he had proven himself to be an excellent strategist, and because he displayed traits of the "ideal" Macedonian. Regardless of his reply, Craterus was eventually assassinated before he could organize a coup with the infantry and Alexander's empire was split into 4 kingdoms.

Alexander's death has been surrounded by as much controversy as many of the events of his life. Before long, accusations of foul play were being thrown about by his generals at one another, making it incredibly hard for a modern historian to sort out the Propaganda and the half-truths from the actual events. No contemporary source can be fully trusted because of the incredible level of self-serving recording, and as a result what truly happened to Alexander the great may never be known.

Alexander's body was placed in a gold anthropid sarcophagus, which was in turn placed in a second gold casket and covered with a purple robe. Alexander's coffin was placed, together with his armour, in a gold carriage which had a vaulted roof supported by an Ionic peristyle. The decoration of the carriage was very rich and is described in great detail by Diodoros.

According to legend, Alexander was preserved in a clay vessel full of honey (which acts as a preservative) and interred in a glass coffin. According to Aelian (Varia Historia 12.64), Ptolemy stole the body and brought it to Alexandria, where it was on display until Late Antiquity. It was here that Ptolemy IX, one of the last successors of Ptolemy I, replaced Alexander's sarcophagus with a glass one, and melted the original down in order to strike emergency gold issues of his coinage. The citizens of Alexandria were outraged at this and soon after Ptolemy IX was killed. Its current whereabouts are unknown.

The so-called "Alexander Sarcophagus," discovered near Sidon and now in the Istanbul Archaeological Museum, is now generally thought to be that of Abdylonymus, whom Hephaestion appointed as the king of Sidon by Alexander's order. The sarcophagus depicts Alexander and his companions hunting and in battle with the Persians.

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Q: How did Alexandria the Great die?
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