How did the Gadsden Purchase effect the career of Mexico's Santa Ana?

Answer 1

At the time, most Mexican people already suspected that Santa Anna had deliberately contributed to Mexico's defeat during the Mexican-American War (1846 - 1848). Even if Santa Anna successfully fended off a belligerent James Gadsden, who demanded the acquisition of all territories north of the parallel 25 N -- which would have included 40% of the remaining Mexican territories after the Mexican-American War -- the treaty was deemed as treason by the Mexican people, resulting in the Revolution of Ayutla (1854 - 1855) and eventually, the Plan of Ayutla (1854) which ousted Santa Anna for good. Having being exiled from Mexico for 19 years, it wasn't until 1874 that Santa anna returned to Mexico, dying of old age two years later.

Answer 2

Mexican leaders were outraged that Santa Ana had made a deal with the US. They believed enough of their land had fallen into the hands of the US. The Gadsden Purchase hastened the end of his political career.