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They didn't. If they had, there would be no Indians to talk about.

Europeans coming to North America way back then brought with them diseases that were quite common -- and ineffectual -- in Europe, where immunities had developed, but deadly in the New World. Yes, there were times when, for example, US Army soldiers were shooting and killing AmerIndians wholesale. But the real slaughter took place on the microbial level.

AmerIndians were helplessly susceptible to diseases carried by European "invaders." Smallpox was especially deadly, but other "minor" diseases like measles and chicken-pox were killers as well.

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Q: How did the europeans wipe out the Indians?
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