How do you convert chlorhexidine solution 2 percent in to chlorhexidine gel 2 percent?

Answer 1

Chlorhexidine (CH) comes in three molecular entities: CH Gluconate, Acetate or Hydrochloride salts. Historically, CH gluconate (CHG) has been the most popular form due to ease of use. CHG comes as a 20% w/v solution. A simple 1 in 10 dilution gives your 2% w/v solution. CH mode of action is a cationic reaction with bacterial cell wall. Therefore, your gel excipients has either to be neutral or cationic as well. There are numerous books on pharmaceutical excipients and jellyfying agents. But keep in mind that the task of creating a gel is not an easy one as you will need to demonstrate In-Vitro efficacy as well as In-Vivo safety (irritation, sensitization,...) and efficacy (capacity to actually redice number of bacterias). I.E. on living human skin. If you are in USA, refer to TFM (Docket 75N-183H) if you are in Canada, refer to Human - Use Antiseptic Drugs. http:/www.hc-sc.gc.ca/dhp-mps/alt_formats/hpfb-dgpsa/pdf/prodpharma/draft_ebauche_antiseptic_guide_ld-eng.pdf

Answer 2

To convert chlorhexidine solution into gel, you would typically need a gelling agent such as carbopol or other suitable thickening agents. You would mix the solution with the gelling agent according to the formulation instructions and allow it to gel before use. It is recommended to use a validated formulation to ensure stability and efficacy.