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Assuming you're not talking about an allergic reaction, no, penicillin has a wide margin of safety and has not been associated with systemic toxicity.

Though you cannot overdose on penicillin, you could end up with severe diarrhea from taking too many at once.

Also, just because you have not had an allergic reaction before to a drug, taking too many could cause an allergic reaction.

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10y ago
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15y ago

Penicillin isn't that kind of drug. You would vomit before you took enough to hurt you. The main side effect of an antibiotic is vomiting and diarrhea.

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10y ago

Overdosing with penicillin can cause symptoms like confusion, behavior changes, a severe skin rash, urinating less than usual, or seizure.

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16y ago

yes you can overdose on any drug

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Q: How do you overdose on penicillin?
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