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Liver is the large organ in your body. It's weight is about 1.5 kg in adult. It gets blood supply from almost all gastrointestinal tract, which has a very large surface area, via portal vein. (About 1200 ml/minute.) It also gets about 300 ml blood from hepatic artery. As liver is a main organ of metabolism, it receives 'direct' supply from portal vein, so that it can handle the challenge of digested food materials. It is the main organ of detoxification and it effectively handle it, unless it is too big like deliberate organophosphorus poisoning.This is called as first pass metabolism. Remaining portion which is not handled in first pass metabolism, is handled subsequently after blood comes to it via hepatic artery. It has got cells from lymphatic system to defend against any microbes, invading the portal vein. This is how it defend your body.

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Q: How does a liver defend your body?
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