It travels down a T-tubule.
Action potential
It attaches to its receptor, and binds. Causes another action potential, (calcium released) and it goes to the T-tubule of the Sarcoplasmic reticulum, and attaches to troponin, which moves the tropomyosin, so the myosin and actin and attach, and cause a muscle contraction.
The mechanism of action of hydralazine is not well known. It interferes with the action of the second messenger IP3, limiting calcium release from the sarcoplasmic reticulum of smooth muscle. This results in an arterial and arteriolar relaxation answer found on Wikipedia
In the fast response action potential of cardiac muscle, the sarcolemma rapidly depolarizes and reaches a plateau. In the plateau phase, Ca2+ released by the glycocalyx comes into the muscle cell from the extracellular fluid. This Ca2+ is called "trigger Ca2+" because it induces the release of Ca2+ from the sarcoplasmic reticulum.
Hyperpolarization (the membrane potential becomes more negative)
When Ach enters the synaptic cleft (gap) it open chemically gated sodium channels that starts an action potential spreading through the sarcolemma of the myofibril. This action potential spreads down the T-tubules and "shocks" the sarcoplasmic reticulum into releasing calcium ions.
sarcoplasmic reticulum
calcium ions.
The Sarcoplasmic Retiulum releases calcium ions that will cause troponin/tropomyosin complex to move. This exposes the binding sites on actin and allows the cross-bridges of myosin to bind to the actin binding sites.
D- contraction phase
Terminal cisterns of the sarcoplasmic reticulum through the Rhynodine receptors release calcium into the skeletal muscle cell when stimulated by an action potential.
Action potential
depolarization
An action potential. It is the nerve impulse that enters into sarcomeres from the sarcoplasmic reticulum and provides the energy for the calcium ions to briefly bind to the troponin on the actin myofilament to allow for contraction to occur by bringing the Z-lines closer together.
It attaches to its receptor, and binds. Causes another action potential, (calcium released) and it goes to the T-tubule of the Sarcoplasmic reticulum, and attaches to troponin, which moves the tropomyosin, so the myosin and actin and attach, and cause a muscle contraction.
despolarization
action potential