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At the cellular level, mad cow disease (BSE or bovine spongiform encephalopathy) is caused by a mis-folded protein that causes other copies of the same protein to mis-fold as well. These mis-folded proteins (called prions) do not function and cannot be broken down by the cell, so they accumulate like so much cellular junk in the cytoplasm until the cell dies from inability to function. The clinical signs at the whole animal level are caused by the deaths of nerve cells.

In contrast, at the cellular level cancer is caused by one or more genetic mutations that cause the cell to divide rapidly and disregard the normal intercellular signals to stop dividing. While there are sometimes significant abnormalities in protein production and function, these are a side effect of the cancer rather than the underlying cause.

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Q: How is cancer different from mad cow disease on a cellular level?
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