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Glucokinase is often referred to as the 'glucose sensor' as it directly relates the rate of β-cell glucose-dependent insulin secretion and the rate of hepatocyte glucose metabolism to the ambient blood glucose level. Read more in related link below.
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What are example of enzymes regulated by feed back?
Glucokinase is the enzyme responsible for phosphorylation of glucose in the first step of glycolysis. The glucokinase complex is modified by two different molecules: citrate and ATP. Citrate and ATP are both products of the sequence of reactions in aerobic respiration and are consequently products of glycolysis. As these two molecules' concentrations in the cell build up, they bind to the allosteric site of glucokinase and shut it down.
What enzyme phosphorylates 90% of the glucose in the liver?
glucokinase
Differences of Hexokinase and glucokinase?
n nHexokinase: Its function is to make sure there is enough glc for the tissues, even in the presence of low blood glc concentrations, by phosphorylating all the glc concentration gradient between the blood and the intracellular environment. n nGlucokinase: Its function is to remove glc from the blood following a meal. n n(Hexokinase, Phosphofructokinase and pyruvate kinase, are 3 regulatory enzymes of glycolysis.) nLiver has an additional enzyme, glucokinase, that phosphorylate only glc n n1. Glucokinase has a high Km because it phosphorylates glc only when its concentration is high. This occurs during the brief period after consumption of a carbohydrate rich meal, when high glc are delivered by portal vein. n n2. Glucokinase has a high Vmax, allowing the liver to remove effectively this flood of glc from the portal blood. So this prevents extreme hyperglycemia after meals. n
Is cyanide a regulated substance in the USA?
It is not 'regulated' as, for instance, narcotics and scheduled drugs are regulated, but it is a highly dangerous poisonous substance and it's sale and use is monitored and tracked.
Name the protein that controls the amount of sugar in the blood?
Insulin is the main regulator of blood glucose.
Which has a higher Vmax: glucokinase or hexokinase?
Glucokinase
Why is glucokinase inactive in the nucleus?
Glucokinase Regulatory Protein is found in the nucleus which binds glucokinase to inactive it
What are example of enzymes regulated by feed back?
Glucokinase is the enzyme responsible for phosphorylation of glucose in the first step of glycolysis. The glucokinase complex is modified by two different molecules: citrate and ATP. Citrate and ATP are both products of the sequence of reactions in aerobic respiration and are consequently products of glycolysis. As these two molecules' concentrations in the cell build up, they bind to the allosteric site of glucokinase and shut it down.
where is glucokinase active intracellularly?
in the cytosol
What is the glucose sensor in B-cells Why?
glucokinase. glucokinase has a high km(low affinity for glucose) so glucokinase only phosphorylates glucose when blood glucose is high, such as after a meal. As such, it makes sense that this would be sensor for B-cells
What enzyme catalyze the phosphorylation of glucose after a meal?
glucokinase
What enzyme phosphorylates 90% of the glucose in the liver?
glucokinase
Which has a higher affinity for glucose: hexokinase or glucokinase?
Hexokinase
What happens if you have a glucokinase deficiency?
You can't produce insulin
Which of the following is characteristic of hexokinase (as opposed to glucokinase)?
It is not inducible by insulin
Where is glucokinase located intracellularly?
equilibriates between the nucleus and cytosol
Where is glucokinase located?
Pancreatic Beta cells and liver hepatocytes. Read more in link.
