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Oliver Wendell Holmes, Sr. (the poet), married Amelia Lee Jackson. They had three children as follows:

1. Oliver Wendell Holmes, Jr. (the Supreme Court Justice)...he married Fannie Bowditch Dixwell and they had no children.

2. Amelia Jackson Holmes....she married John Turner Sargent and they too were childless.

3. Edward Jackson Holmes, Sr....he married Henrietta Goddard Wigglesworth and they had only one child, Edward Jackson Holmes, Jr. or "Ned" as he was known.

Edward Jackson Holmes, Jr., the only grandchild of Oliver Wendell Holmes, Sr., married Mary Stacy Beaman, who was my great grandmother's sister. They unfortunately had no children and thus, Ned Jr. was the end of the Holmes line.

Source: http://genforum.genealogy.com/holmes/messages/1959.html

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Q: How many siblings did Oliver Wendell Holmes Jr have?
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