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Is Down syndrome more severe in mitotic nondisjunction or meiotic nondisjunction?
Wiki User
∙ 11y ago
It's more sever in meiotic nondisjunction, since this is the most common way that trisomy 21 (Down syndrome) arises. mitotic nondisjunction is less sever because it means that some cells will be mosaic, meaning they could be normal while some with have the (2n+1) while other cell will be (2n). So, in mitotic nondisjunction it depend how many cells are carrying the extra 21 chromosome. In end of the day they can't be worse than Down syndrome that rose from meiotic nondisjucntion since it has the highest amount of cells carrying trisomy 21..
I hope this helps
Wiki User
∙ 11y ago
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