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Is heroin water or fat-soluble

Updated: 8/10/2023
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13y ago

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Basic Chemistry; As Heroin in the salt form i.e Heroin Hydrochloride it is water soluble. As the freebase it is NOT water soluble which is why citric acid is added to freebase Heroin to make it injectable. Look in your medicine cabinet; how many pills say eg Prozac HCl (hydrochloride). As for lipiphilicity (fat solubility), it is the advantage of heroin where legally used; like the UK, that as freebase it is extremely fat soluble so it rapidly crosses the blood/brain barrier and produces a 'rush'. Briefly, 'crack'cocaine is a freebase but cocaine HCl is the stuff folks put up their noses. Curiously Heroin. HCl has a high enough vapour pressure to be smokeable, unlike cocaine HCl. Also many acids can make a freebase alkaloid water soluble.

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13y ago
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15y ago

Its most common form, heroin hydrochloride, is. Heroin base is not soluble in water but is rarely sold on the street.

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