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Pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. The underlying mechanism is that the gene codes for a product that is for example used by various cells, or has a signalling function on various targets. A classic example of pleiotropy is the human disease PKU (phenylketonuria). This disease can cause mental retardation and reduced hair and skin pigmentation, and can be caused by any of a large number of mutations in a single gene that codes for an enzyme (phenylalanine hydroxylase) that converts the amino acid phenylalanine to tyrosine, another amino acid. Depending on the mutation involved, this results in reduced or zero conversion of phenylalanine to tyrosine, and phenylalanine concentrations increase to toxic levels, causing damage at several locations in the body. PKU is totally benign if a diet free from phenylalanine is maintained.
Wiki User
∙ 15y ago
Wiki User
∙ 14y agoyes-"Pleiotrophic alleles are responsible for the multiple symptoms associated with certain hereditary diseases, such as cystic fibrosis and sickle-cell disease".
Biology vol 1 Campbell 8th edition
Wiki User
∙ 12y agoYes - sickle cell anaemia is caused by a mutation in the haemoglobin gene.
Wiki User
∙ 13y agoyes
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When was sickle cell anemia discovered?
Sickle cell anemia was discovered in the 1870's and carried many names, but 1922 it was officially named sickle cell anemia.
Is sickle cell anemia a type of poikilocytosis?
Yes, drepanocytosis(sickle cell anemia) is a type of poikilocytosis.
What cell mutation can be inherited?
Sickle cell anemia is an example of a cell mutation that can be inherited.
Is sickle cell anemia x-chromosome or non x-chromosome?
Sickle cell anemia is not sex linked.
You have sickle cell anemia what will folic acid do for your sickle cell anemia?
ITS GOOD 4 UR SICKLE CELL! When you have sickle cell, your body looses cells. Folic acid helps to create new cells.
Sickle-cell anemia is an example of a point-mutation?
An example of point-mutation is sickle-cell anemia. Sickle-cell disease is hereditary.
Is sickle cell anemia a point mutation?
An example of point-mutation is sickle-cell anemia. Sickle-cell disease is hereditary.
Is sickle cell anemia example of poikilocytosis?
No
Can a disease cure a disease For example Can Cancer be cured by Sickle Cell Anemia?
well no cancer can not be cured by sickle celled anemia because sickle cell is the abnormalty of the shape of the cell.
What is Sickle-cell anemia is an example of?
Genetic disorder
How do you ge sickle cell anemia?
You get Sickle-Cell Anemia by Birth,it is a genetic disorder.
Is sickle cell anemia an example of balanced polymorphism?
Yes. This answer is TRUE.
Is sickle cell anemia recessive or dominant?
Sickle cell anemia is an autosomal recessive disease. Carriers have sickle cell trait, which confers resistance to malaria.
Is Sickle cell anemia genetic?
Yes, Sickle Cell Anemia is in fact a genetic disorder.
What is a genetic autoimmune difficiency in which blood cells look like a sickle It is not sickle cell anemia?
sickle cell anemia
Is sickle cells disease hereditary?
Sickle cell anemia -yes it is hereditary
When was sickle cell anemia discovered?
Sickle cell anemia was discovered in the 1870's and carried many names, but 1922 it was officially named sickle cell anemia.
