Is solifenacin succinate indicated in uti?

Answer 1

no.

Solifenacin succinate is indicated to treat overactive bladder, also known as urge incontinence.

A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects the lower urinary tract it is known as a simple cystitis (a bladder infection) and when it affects the upper urinary tract it is known as pyelonephritis (a kidney infection). Symptoms from a lower urinary tract include painful urination and either frequent urination or urge to urinate (or both), while those of pyelonephritis include fever and flank pain in addition to the symptoms of a lower UTI. In the elderly and the very young, symptoms may be vague or non specific. The main causal agent of both types is Escherichia coli, however other bacteria, viruses or fungi may rarely be the cause. Women are generally affected more often than men. The most common symptoms are burning with urination and having to urinate frequently (or an urge to urinate) and significant pain, during urination especially, but in general as well.. These symptoms may vary from mild to severe. Some pain above the pubic bone or in the lower back may be present. People experiencing an upper urinary tract infection, or pyelonephritis, may experience flank pain, fever, or nausea and vomiting in addition to the classic symptoms of a lower urinary tract infection. Rarely the urine may appear bloody or contain visible pyuria (pus in the urine). In certain people, symptoms may be different from the above. In young children, the only symptom of a urinary tract infection (UTI) may be a fever. In older children, new onset urinary incontinence (loss of bladder control) may occur. Urinary tract symptoms are frequently lacking in the elderly The presentations may be vague with incontinence, a change in mental status, or fatigue as the only symptoms. While some present to a health care provider with sepsis, an infection of the blood, as the first symptoms. Diagnosis can be complicated by the fact that many elderly people have preexisting incontinence or dementia.

From past experience, I know that it is possible, but not overly likely that people can have UTIs that are asymptomatic until they get to a more serious stage when fever, nausea and vomiting are present. I have a long (20+yrs) history of occasional UTIs and so I know the symptoms all too well. I could tell, at a fairly early stage, when I'd be getting an infection and was usually able to get rid of them using at home remedies with only a handful requiring antibiotics. But, from about 2007 on, I had a problem where I had NO clue I had a UTI until I had a urine analysis as part of an ER workup. I had symptoms of the stomach flu, and because of medications I am on (some of which suppress my immune system) I cannot miss some of those meds or become dehydrated. So when the stomach flu hits, and lasts longer than 24 hrs or so, I need to get fluids and medications in my body, which means I get to go to the ER if it occurs on a weekend. I had a few ER trips for what seemed to be the stomach flu but always ended up with being treated for that but also being treated for a UTI. After the third time, I told the ER I thought it was the stomach flu, but that I might also have a UTI since my prior experiences proved that to be true.

In uncomplicated cases, urinary tract infections are easily treated with a short course of antibiotics, although resistance to many of the antibiotics used to treat this condition is increasing. In complicated cases, longer course or intravenous antibiotics may be needed, and if symptoms have not improved in two or three days, further diagnostic testing is needed. In women, urinary tract infections are the most common form of bacterial infection with 10% developing urinary tract infections yearly. Phenazopyridine (Pyridium) is occasionally prescribed during the first few days in addition to antibiotics to help with the burning and urgency sometimes felt during a bladder infection. Oral antibiotics such as trimethoprim/sulfamethoxazole (TMP/SMX), cephalosporins, nitrofurantoin, or a fluoroquinolone substantially shorten the time to recovery with all being equally effective. A three-day treatment with trimethoprim, TMP/SMX, or a fluoroquinolone is usually sufficient, whereas nitrofurantoin requires 5-7 days. With treatment, symptoms should improve within 36 hours. About 50% of people will recover without treatment within a few days or weeks.

Overactive bladder (OAB) is a urological condition defined by a set of symptoms: urgency, with or without urge incontinence, usually with frequency and nocturia. Frequency is usually defined as urinating more than 8 times a day. (Notice the lack of bacterial, viral or fungal cause.) there may be multiple possible causes. It is often associated with overactivity of the Detrusor urinae muscle, a pattern of bladder muscle contraction observed during urodynamics. Treatments for OAB are usually synonymous with treatments for detrusor overactivity. OAB is distinct from stress urinary incontinence, but when they occur together, the condition is usually known as mixed incontinence.

Treatment for OAB includes lifestyle modification (fluid restriction, avoidance of caffeine), bladder retraining, antimuscarinic drugs (e.g. darifenacin, hyoscyamine, oxybutynin, tolterodine, solifenacin, trospium, fesoterodine), β3 adrenergic receptor agonists (e.g. mirabegron), and various devices (Urgent PC Neuromodulation System, InterStim). Botulinum toxin A (Botox) is approved by the FDA in adults with neurological conditions, including multiple sclerosis and spinal cord injury. Botulinum Toxin A injections into the bladder wall can suppress involuntary bladder contractions by blocking nerve signals and may be effective for up to 9 months. A surgical intervention involves the enlargement of the bladder using bowel tissues, although generally used as a last resort. This procedure can greatly enlarge urine volume in the bladder.

As a result of repeated UTIs over the course of an 11 mo span, in combination with a being catheterized frequently, as well as being bed-bound, I became completely incontinent for a time. That was the least of my worries at the time, as I was facing multiple potentially life-threatening infections, problems with being able to control nausea and vomiting, which lead to a weight loss of more than 100lbs as well as being told I'd never walk again. So needless to say, the issue of continence was not as much of a concern as staying alive, being able to keep food down, etc. After awhile, I progressed to a point that was not thought possible. I walk now, albeit rather slowly and with the aid of crutches as well as frequently using a wheelchair because of extreme fatigue and pain. But, I also made improvements with regard to no longer being totally incontinent. Now, I deal with a form of mixed bladder incontinence. For me, it's mostly in the form of OAB/urge incontinence where I am frequently using the bathroom along with some stress incontinence. If I were not dealing with the mobility issues, I'd not have as much of a problem. But when you cannot walk quickly and the urge to use the bathroom doesn't hit early enough that you have time to get up and walk to the bathroom, it can be quite a problem. I do take solifenacin succinate and it helps quite a bit. It's not a perfect solution. But for those times I get a UTI, I still must take an antibiotic. Solifenacin succinate does absolutely NOTHING for a UTI.