The 2010 Lexus RX-350 has front wheel drive.
The 2010 Lexus RX-450H has front wheel drive.
The 2010 Lexus ES-350 has front wheel drive.
The 2010 Lexus IS-350 has rear wheel drive.
The 2010 Lexus IS-250 has rear wheel drive.
The 2010 Lexus GS-450H has rear wheel drive.
The 2010 Lexus LX-570 has four wheel drive.
The 2010 Lexus IS-350-C has rear wheel drive.
The 2010 Lexus LS-460 has rear wheel drive.
The 2010 Lexus GX-460 has four wheel drive.
The 2010 Lexus IS-250-C has rear wheel drive.
The 2010 Lexus GS-350 has rear wheel drive.