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Is the process of demyelination in peripheral neuropathy stopped or reversed by the use of Mecobalamin?
Wiki User
∙ 12y ago
I believe the person asking the question intended to say "Methylcobalamin." Methylcobalamin is a form of B12 (opposed to Cynocobalamin) Where Cyno=Cyanide. The Methyl form replaces the Cyanide with a Methyl donor. It is also useful for lowering Histamine levels in the brain in Under-methylated individuals.
AnswerI'm not sure what mecobalamin is. Cyanocobalamin, or vitamin B12, is necessary for repairing the damage done by demyelination. I'm not sure if there is anything that can reversedemyelination, if the root cause of the demyelination cannot be obliterated. Folic acid and vitamin B6 also seem to help with the repair. If you lacked in lactose (milk sugar) as a baby, you may not be helped by the above 3 - B vitamins, as the myelin sheath must have had galactose (one of the simple sugars of lactose) as it was developing in the infant child. So, for example, if you were raised on soy milk without a lactose sugar supplement, you may not have the necessary building blocks to repair your myelin sheath. Also, if the myelin sheath destruction (demyelination) rate is faster than the repair, you are ultimatley fighting a loosing battle. I am not an expert on this topic, but am telling you what I have discovered along the way, being a sufferer of demyelination, myself.Wiki User
∙ 12y ago
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What is the prognosis for patients with early stage diabetic neuropathy?
Small fiber neuropathy manifests in a variety of different diseases and often results in symptoms of burning pain, or shooting pain. The variety of diseases that may result in a small fiber neuropathy, include diabetes and other glucose dysregulation syndromes, thyroid dysfunction, sarcoidosis, vitamin B12 deficiency, HIV, neurotoxic medications, celiac disease, paraneoplastic syndromes, and paraproteinemias. Despite extensive diagnostic evaluation, majority with small fiber neuropathy ultimately may be given a diagnosis of chronic pain.
Where does neuropathy come from?
Despite the fact that this is posted in the dermatorlogy section and that the sensation (burning pain, heaviness, cold, pins/needles, etc) can be felt in the skin, this is not a skin problem. Neuropathy is a nerve issue, generally the peripheral nerves such as those that lead to the arms, wrists or hands/legs, shins or feet. The causes are numerous and can include diabetes (very common) arthritis, injury, contraindications (bad reactions) to medication, vitamin deficiency or excess, or even heavy metal poisoning. This is not something to treat over the internet, and should be addressed by a board certified neurologist or pain management specialist. Neuropathy can often be treated by mediations containing anti-convulsants (anti-seizure medication) to slow down the excitable neurons. There are also many physical therapy techniques that can reduce the annoying and/or painful symptoms. Take away message: neuropathy is not a normal part of aging and is something that should be examined by a doctor and treated as soon as possible. Its course can often be reversed, but can become permanent if not addressed.
What can relieve peripheral neuropathy pain?
There are many different treatments for neuropathy. They are:Neurontin - gabapentin & Lyrica - They are antiepileptic drugs prescribed for neuropathy - possible side effect, however, is neuropathy (see manufacturer's literature) All drugs have side effects.Methylcobalamine (B12) and folic acidRebuilder - combines a footbath with an electrical current. Claims to open up nerve channels and stimulate circulation.Anodyne Therapy - infrared light to increase circulatioen and stimulate production of nitric acid. It is supposed to relax the arteries and elminates free radicals. Pads are put over the injured areas. Pain is supposed to be relieved with increased circulation and more Nitric Oxide in the boood.Alpha lipoic acid which as an anti-oxidant attempts to protect the nerves that no further damage is done to the body. It can help with the symptoms,It is becoming widely known that certain special forms of B vitamins have a lot to do with repairing nerve damage. Some people have tried large amounts of ordinary B1, B12 or B complex vitamins and they find that it does not help them. Ordinary B vitamins are water-soluble and they wash out of the body long before they get to the required levels needed in your blood stream sot that it can begin repairing nerve damage.A type of B1 called Benfotiamine is a fat soluable B so that the body can hold onto the vitamin long enough to be used. There is a type of B12 called Methyl B12 that is a converted B12 that can be easily absorbed by the body.
Causes of Neuropathy Symptoms Vary Widely?
The symptoms associated with neuropathy vary, depending upon where the affected nerve is located in the body. Damage may have occurred to one or more types of nerves. Some symptoms that are commonly seen in cases of neuropathy are cramps, spasms, and muscle weakness. Occasionally, neuropathy can cause symptoms that include loss of balance and muscle coordination. Nerve damage can also cause numbness, pain, and tingling in affected areas. The pain seen in neuropathy is typically described as "freezing, burning, or like an electrical charge", or "extreme sensitivity to touch". Neuropathy usually refers to cases of peripheral neuropathy or damage to the peripheral nervous system. It could be caused by disease processes or the side effects of certain illnesses. Some cases of neuropathy affect only one nerve. This type of nerve damage is known as "mononeuropathy". Mononeuropathy is usually caused by the nerve being physically compressed. One well known example is carpal tunnel syndrome- a disorder caused by compression of the nerves in the hand and wrist. The common feeling of "pins and needles" is one example of nerve compression, although temporary in duration. The usual cause is temporary interruption of the blood supply to the affected area, such as when a sleeper lies on their hand or arm for an extended period. Polyneuropathy is another type of neuropathy where nerve cells in multiple areas of the body are affected, most commonly caused by diabetes. The myelin covering of nerve cells are degraded, which prevents electrical impulses normally generated by these cells from being transmitted properly. This causes symptoms in multiple parts of the body, many times they are experienced on both sides of the body at one time. The main symptoms are muscle weakness and lack of coordination, tingling or burning, and dizziness. In addition to diabetes, other potential causes of polyneuropathy include vitamin deficiencies, lyme disease, toxins, and blood disorders. This type of neuropathy usually progresses very slowly, but occasionally can be more rapid in its advance. If symptoms are caused by high glucose levels associated with diabetes that can often be reversed with changes in diet and exercise.
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