Is your hamster scared if she poops excessively when picked up or is this normal?

This is pretty normal for a hamster. They do get nervous and the pooping may be more frequent when handled. Hamster do tend to poop a lot and whenever they need to so it doesn't matter if you are picking it up or not. Just check to make sure the poop is solid not runny. Runny poop can be a sign of wet tail. If this happens, bring it to the vet!