Location of turn signal flasher 2000 Jeep Grand Cherokee?

It's located above the fuse panel, below and to the left of the steering wheel. You'll need to remove the upper and lower dash trim around the steering wheel. In your service manual there should be a fuse and relay diagram, the one you're looking for is the "Flasher" unit. On my 99 Laredo it is at the very top of the unit (in a hard to reach space) third from the left. The relay is about twice the size of the other relays. Try jiggling it around before replacing, in my case it wasnt quite seated properly.