0
LCMSMS-3200
LINEARITY RANGE:5-800 ng/mL
EXT PROCEDURE:0.250 mL +50µL ISTD(Nitrofurantoin 13c3)+2.5 mL Ethyl acetate)-vortex,centrifuge and transfer 2.0 mL supernaunt and evaporate till dry at 40C and reconstitute 0.250 ml Mobile phase(10 mM ammonium acetate :MeoH-5:95)
column:phenyl column-c18
What else can I help you with?
Why calibration curve method is more reliable as compared to a single point method?
Why Calibration curve method is more reliable than single point method?Read more: Why_Calibration_curve_method_is_more_reliable_than_single_point_method
What is the significance of the development of the cyanmethemoglobin method?
The development of the cyanmethemoglobin method is significant in hematology and clinical medicine because it allows for accurate measurement of hemoglobin levels in blood samples. This method is considered more reliable than older techniques and has become a standard in blood testing due to its precision and reproducibility. It is particularly important for diagnosing and monitoring conditions such as anemia and other blood disorders.
Why did Richard R. Schrock win The Nobel Prize in Chemistry in 2005?
Richard R. Schrock won the Nobel Prize in Chemistry in 2005 for his work on the development of the metathesis method in organic synthesis. This method allows for the efficient and environmentally friendly production of complex molecules, which has had a significant impact on the fields of pharmaceuticals, materials science, and biotechnology.
What is the method used for conducting skeels and dye experiment?
The Skeels and Dye experiment was conducted in an orphanage to study the effects of intelligence testing on children's development. The experiment involved giving intelligence tests to some children and not others, and then assessing the impact on their development over time. The results of the study suggested that intelligence testing did not have a significant impact on the children's development.
The work of which scientist was most essential to use the scientific method and quantitative in chemistry?
Antoine Lavoisier was the scientist whose work was most essential in applying the scientific method and quantitative methods in chemistry. His work on the conservation of mass and the development of the chemical element system were pivotal in the advancement of modern chemistry.
Linearity is how much important in method validation?
its important for recover the calculation equation and for improve linearity equation (pears low )
How many parameters will perform in analytical cleaning method validation?
linearity, Recovery for soaping , recovery for stainless plate and LOD & LOQ
What is the definition of method development by hplc?
Method development is a process amenable to continuous improvement
Difference between linearity and range in analytical method validation?
The previously recorded answer in inaccurate on several levels (see below for quotations of previous repsonse)Linearity is the correlation of a regression line. Range is typically derived from linearity. Range implies that the method developed corresponds to the "range"between 80-120% (ideally) of the expected sample range (concentration, wt. etc). For content uniformity, range is expected to be 70-130% of the test concentration. These are guidelines governed by ICH Q2 R1 (International Conference for Hamonisation).In terms of HPLC method development:LOQ is the smallest amount that will give a S/N ratio of 10 meaning this is the smallest amount you may give a numerical value with confidence. TYPICALLY, THE LOWER RANGE (AND USUALLY LINEARITY) IS LOQ.LOD is the smallest value that will give an S/N ratio of 3, meaning you can say the specific compound is there qualitatively, but not quantitate the compound.Previous:"The range is any value that lies between the limit of detection (LoD) and the limit of quantitation (LoQ). Where the LoD is the lowest concentration that can be accurately measured and the LoQ is the highest concentration that can be accurately measured.Linearity describes the correlation to a regression line that has been fit to the data that. For some nice pictures to explain this see regression line at:"
How to Calculate Pressure Transmitter Accuracy?
accuracy with only one variable. Accuracy takes into account several different variables, only one of which is non-linearity. In other words, non-linearity alone does not determine a device’s overall accuracy. These are the five variables a user should consider when determining pressure transmitter accuracy: Two methods are used to generate the reference line needed to find a pressure transmitter’s non-linearity: the terminal method, also called endpoint method (blue line) and the best fit straight line method (brown line). The linearity is the largest deviation from the reference line to the actual response (red line). Non-linearity Non-linearity is the largest deviation between the actual response (red curve) and a reference line. There are two common methods for generating this reference line The terminal method, also called the endpoint method, draws a straight line from the actual zero point to the actual full scale value endpoint. Since this method is based on the characteristic curve’s endpoints, it is a truer representation of a pressure transmitter’s non-linearity. The best fit straight line (BFSL) method is a straight line that stays within a certain percentage deviation from the characteristic curve, or actual response. The endpoints do not figure into this method. BFSL method values are typically half of terminal method values, meaning that a pressure transmitter with a ±0.25% BFSL non-linearity allows for a ±0.50% error. Zero offset and span tolerance when calculating pressure transmitter accuracy Zero offset The zero offset is the deviation between the ideal line’s zero point and the characteristic curve’s zero point (see Fig. 4). Span tolerance Span tolerance is the deviation of the actual span from the ideal span between the zero point and the full scale point. The span offset is not related to the zero offset and has to be added to it. Hysteresis Hysteresis is the lag between a change in pressure and the corresponding change in the pressure transmitter signal. It is an indication of how fast or slow a pressure transmitter responds to input changes. Non-repeatability Non-repeatability is the maximum difference in the signal of the pressure transmitter for the same applied pressure. It is an indication of how much the transmitter duplicates measurements for the same input.
What is adhoc system development method?
this is the development of a system as at when it is required.
What is cadm?
CASE Application Development Method
What are the guidelines for method development of hplc according to ich?
the same guidelines for method validation
What are the validation parameters for related substance by hplc analysis?
The validation parameters for related substances analysis by HPLC typically include specificity, linearity, accuracy, precision, detection limit, quantification limit, and robustness. Specificity ensures the method can differentiate between the analyte and impurities, while linearity confirms a linear relationship between concentration and response. Accuracy and precision assess the closeness of results to the true value and the method's repeatability. Detection and quantification limits determine the lowest concentration that can be reliably detected and quantified. Robustness evaluates the method's ability to remain unaffected by small variations in parameters.
What is paragraph development by combined method?
combined paragraph development method is a type of methods in which at least 2 types of paragraph development methods are used . Clearly , mix of at least 2 other types .
Procedure adopted under the scientific method in development under the economic theory?
Describe the procedure adopted under the scientific method in the development of economic theories
What is the method for development of dish end plate fro pressure vessels?
how to development of dish end in auto cad
