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What is rs-hplc?
"RS-HPLC method" means "Related Substance HPLC Method".
What is RRT and RRF in hplc?
In HPLC RRT means Relative Retention Time and RRF is Relative Response Factor
What is an HPLC column?
HPLC Column is one type of tube containing a stationary phase react with mobile phase to detect peak
What are the HPLC Calibration parameters and elaborate it?
1. Flow rate 2. Temp. of column 3. Detector function 4. Resolution
Whayt is the definition of Non halogenated volatiles?
The definition of non-halogenated volatiles is a compound where a halogen is not attached. They are mainly analysed based on their solubility in water.Ê
What are the guidelines for method development of hplc according to ich?
the same guidelines for method validation
What is rs-hplc?
"RS-HPLC method" means "Related Substance HPLC Method".
What has the author Sukwinder Kaur Gill written?
Sukwinder Kaur Gill has written: 'Development of a method for the determination of chlortetracycline (CTC) in a three component mixture (Microfac) by HPLC'
Why is anthracene is used for calibration of hplc?
Anthracene is used as a calibration standard in High Performance Liquid Chromatography (HPLC) because it has a well-defined retention time and peaks in the UV-visible spectrum, making it easy to detect and quantify. Its consistent behavior helps in determining retention times, resolving power, and column efficiency during method development and troubleshooting in HPLC.
What are the 11 methods of paragraph development and their example?
what are the 11 method of developmental paragraph? and give each example
Definition of child development?
definition of development
Definition of standard in HPLC?
In HPLC, a standard is a known compound with a defined chemical structure and purity used for comparison and identification purposes. Standards are essential for calibrating instruments, determining retention times, and quantifying unknown compounds in samples during analysis.
what are the Method of paragraph?
there are 11 methods of paragraph development. They are: *definition *comparison & contrast *details *illustration *analogy *repetition *cause and effect *elimination *question and answer *enumeration *combined method
Why reproducibility is important in hplc?
Reproducibility in HPLC ensures that results can be consistently obtained when the experiment is repeated, leading to reliable data. It allows for verification of results by other researchers and ensures the accuracy and reliability of the method. Reproducibility is crucial for validating the robustness of the HPLC method and for ensuring that results are accurate and can be trusted.
How you can select buffer in hplc according to pka value?
In HPLC, you can select a buffer based on its pKa value to achieve better separation of analytes by controlling pH of the mobile phase. Choose a buffer with a pKa value close to the desired pH for the separation, as this ensures the buffer will be most effective in maintaining stable pH. Selecting a buffer with a pKa within ± 1 unit of the desired pH is a commonly used guideline in HPLC method development.
How you find out Pka value of organic compound for HPLC method develoment?
If you can't find it in the literature it can be determined experimentally by titration.
Why the pH of buffer is not changes in robustness of validation of hplc method?
it must change by (+- 0.3) to have control in pH meter error
