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What are the guidelines for method development of hplc according to ich?
Wiki User
∙ 13y ago
the same guidelines for method validation
Wiki User
∙ 13y ago
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What is the definition of method development by hplc?
Method development is a process amenable to continuous improvement
What is rs-hplc?
"RS-HPLC method" means "Related Substance HPLC Method".
Asenapine maleate method of analysis by HPLC?
yes
What has the author Sukwinder Kaur Gill written?
Sukwinder Kaur Gill has written: 'Development of a method for the determination of chlortetracycline (CTC) in a three component mixture (Microfac) by HPLC'
What is assay by HPLC?
HPLC is high-performance liquid chromatography. This method is used for the separation and production of chemicals but also for chemical analysis.
What is difference between specificity and selectivity in hplc method validation?
specificity and selectivity
In hplc validation according to ich guidelines loq is 10 times of sn ratio but you are doing 6times of it is there any guidelines from you?
'Actually for LOQ precision there is no guidelines, but LOQ definition is to be actually quantified with accuracy and precision. That,s why to conform the precision we are injecting six times and find the rsd less than 10%. It shows that LOQ is able to quantify with accuracy and precision
How buffer concentration effects on retention time in hplc method?
concentration of buffer effects in buffer strength
What analytic method is more preferrable betwee GC and HPLC?
Whether GC or HPLC is a more preferable analytical method depends on the material being analyzed for, the likely concentration in which it is found, and what medium it may be in/on (water, oil, different kinds of filters, etc.) There is no single, universally applicable answer.
How you find out Pka value of organic compound for HPLC method develoment?
If you can't find it in the literature it can be determined experimentally by titration.
Why the pH of buffer is not changes in robustness of validation of hplc method?
it must change by (+- 0.3) to have control in pH meter error
How do you distinguised np-hplc and rp-hplc?
NP-HPLC is "Normal Phase" HPLC, wherein the solvents used are less polar than the substrate in the HPLC column (e.g. using hexane or dichloromethane with a silica HPLC column). RP-HPLC is "Reverse-Phase" HPLC, wherein the solvents used are more polar than the substrate in the HPLC column (e.g. using Water and Methanol with a octadecylsilane (ODS or C18) column).
