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The BRCA 1 and BRCA 2 mutations increase the risk of which cancer in women?
Wiki User
∙ 10y ago
Yes, but the BRCA1 and BRCA2 tests can also be negative.
Wiki User
∙ 10y ago
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What does BRCA stand for?
BRCA1 and BRCA2 are genes that can mutate into cancer.
What mutagen causes breast cancer?
Well the onco genes are BRCA-I and BRCA-II if mutated they cause breast cancer, I think that is what you meant, if not then you may have learned something new anyway
What is the most common cause for endometrial cancer?
The cause of breast cancer is not fully understood. Heredity or genetically related susceptibility is considered to play a role. Hormonal regulation of the breast is related to the development of breast cancer, but the mechanisms are poorly understood. Sex hormones (like estrogen) may act as a tumour promoters id initiating agents have induced malignant changes. Estrogen doesn't cause Breast Cancer, but the initiating agents that are found in a susceptible person may accelerate its growth. Additional factor under study include physical inactivity, dietary fat intake, obesity, and alcohol intake. Environmental factors such as chemical, pesticide, and radiation exposure may also play a role. Gene abnormalities may be inherited. 5 to 10 percent of all breast cancer persons inherit this gene. Tumour suppressor genes BRCA-1 gene, located in chromosome 17 is a tumour suppressor gene that inhibits tumor development when functioning normally. Women who have BRCA-1 mutations have a 50-85 percent lifetime chance of developing breast cancer. BRCA-2 is another culprit. BRCA tumor suppressor genes mutations may account for 10-40 percent of breast cancers.
What does BRCA mean?
BRCA1 and BRCA2 are two genes in your DNA which when altered or mutated, leads to Breast cancer.
Is breast cancer disease genetic communicable enviromental oe behavioral?
Breast cancer has a bit of all.The genetic cases only make up around 5% of all cases (check out BRCA 1 and BRCA 2 genes).The environment definitely impacts on it (eg. smoking).I guess behavioral falls into environmental.However, the great majority is just random, that's why it's important to get screened regularly, espacially for women over 40.
What is the genetic basis of cancer?
Some cancers show a genetic predisposition - for example BRCA Mutation a form of breast CA.
How do the BRCA genes function differently in a person with the mutation?
The BRCA genes are involved in initiating DNA repair and cell cycle check points, they as as regulators of other tumour supressors genes such as p53 and help the cell repair and damage which may lead to cancer occurring in the cell. In mutant versions of the BRCA genes they cannot perform their roles and damaged DNA may cause the cell to replicate uncontrollably as check point to prevent this has been removed. Genome stabiliy is affected and cancer can develop
Is breast cancer hereditary?
HereditaryBreast CancerAccording to the National Institutes of Health, breast cancer can be a hereditary condition. However, hereditary breast cancer only accounts for 5%-10% of all breast cancer cases involving inherited gene mutations. Hereditary breast cancers often occur in younger women and involve both breasts. Regardless, when the family history is strong for development of breast cancer, a woman's risk is increased.AnswerThere are tests (BRCA 1,2 and 3) to see if you have a genetic link for breast cancer. However, having one of these marks will not tell if and when you will get breast cancer. There are many other factors for getting breast cancer (estrogen lifetime exposure, alcohol/cigarette use, etc).Men also have a hereditary risk and those with multiply family members with breast cancer histories should be particularly careful to report changes to their physician.It can be. It is possible to inherit mutated BRCA1 or BRCA2 genes that can greatly increase your risk of breast cancer.
What percentage of breast cancer is down to a genetic fault?
5% of breast cancer is down due to a genetic fault. These genes are passed down through abnormal genes passed from parent to child. An example of this is the BRCA genes.
What does BRCA 2 control?
you can figure it out
Do parents with skin cancer pass it on to their offspring?
Yes, there certainly is a heredity factor with Crohns disease. Many studies have shown that those families with prior members affected will have as much as a 20% higher risk of seeing it in the same family.
Do woman get prostate cancer?
Women do not classically get prostate cancer as cancer of the prostate is classified as a disease of the prostate gland of the male reproductive system. However, in 2002 the female Skene's Gland was officially renamed the female prostate as it was found to be homologous in function. Both male and female prostates produce Prostate Specific Antigen (PSA) and contribute to the ejaculate fluid. Six cases of adenocarcinoma have been observed as originated from the female prostate that strongly resemble that of classical male prostate cancer. Serum tests showed elevated levels of PSA, typical in prostate cancer.
