lactose metabolizing enzymes need not be made when lactose is not present.
The mechanism by which the presence of glucose inhibits the arabinose operon is catabolite repression. The lac operon is responsible for the metabolism of glucose.
Lac operon is a set of genes that regulates the digestion of lactose. In absence of lactose in the medium, the repressor protein binds to the operator that inhibit the transcription of structural genes such as beta galactosidase, lactose permease and transacetylase. This makes sure to avoid the enzyme synthesis when there is no need!Conversely, when the lactose present in the medium, an isomer of lactose called allolactose bind to the repressor protein, the conformational change in the repressor let it to detach from repressor hence the RNA polymerase can transcribe the structural gene. Although this may be enough for synthesis of structual gene the system is tightly regulated by a protein called CAP (catabolite activator protein) and glucose.Glucose is a preferred source of energy for cell when this desirable source is present, lactose need not be used as a energy resource. What happens is there will be low level of cAMP when there is high amount of glucose and this keeps CAP inactive.When there is low glucose levels, the cAMP would be higher, that binds to CAP to make it active, which in turn binds to the promoter that enhance the transcription of structural genes.Thus, for efficient transcription lac operon structural genes, lactose must be present where glucose must be absent.
Digestive System.
the digestive system
Saturn!
http://en.wikipedia.org/wiki/Lac_operon
When the lac operon controls the expression of proteins in the E.coli cell that can break down lactose into two sugars, glucose and galactose. When lactose is present, it binds to the repressor that typically sits on the lac operon, changing the repressor's conformation such that it can no longer bind to the lac operon. Because of this, RNA polymerase can now transcribe the gene into mRNA, which in turn is translated into the proteins that can break down lactose.
The mechanism by which the presence of glucose inhibits the arabinose operon is catabolite repression. The lac operon is responsible for the metabolism of glucose.
Lactose Intolerance occurs in the digestive system.
Lac operon is a set of genes that regulates the digestion of lactose. In absence of lactose in the medium, the repressor protein binds to the operator that inhibit the transcription of structural genes such as beta galactosidase, lactose permease and transacetylase. This makes sure to avoid the enzyme synthesis when there is no need!Conversely, when the lactose present in the medium, an isomer of lactose called allolactose bind to the repressor protein, the conformational change in the repressor let it to detach from repressor hence the RNA polymerase can transcribe the structural gene. Although this may be enough for synthesis of structual gene the system is tightly regulated by a protein called CAP (catabolite activator protein) and glucose.Glucose is a preferred source of energy for cell when this desirable source is present, lactose need not be used as a energy resource. What happens is there will be low level of cAMP when there is high amount of glucose and this keeps CAP inactive.When there is low glucose levels, the cAMP would be higher, that binds to CAP to make it active, which in turn binds to the promoter that enhance the transcription of structural genes.Thus, for efficient transcription lac operon structural genes, lactose must be present where glucose must be absent.
The repressor protein blocks the genes from making mRNA.
Digestive System.
Digestive System.
Lactose intolerance is the inability to metabolize lactose, because of a lack of the required enzyme lactase in the digestive system.
the digestive system
Lactose intolerance occurs when the digestive system is no longer able to metabolise the sugars (lactose) found in dairy products through producing insufficient amounts of an enzyme called lactase.
It allows lactose to permeate the cell membrane, and then break bonds with glucose and galactose to use the lactose for food.