US President Franklin Delano Roosevelt was often referred to by his initials FDR.
Zachary Taylor was known as "Old Rough and Ready".
In 1961 JFK was president so the answer to your question is JFK.
Gen. Winfield Scott, who ran for president against Pierce in 1852, was known as a fussbudget and had the nickname of 'Old Fuss and Feathers." I have not heard the nickname ascribed to any president.
Woodrow Wilson was nicknamed "The Professor." I found this answer through a Google search so if it is incorrect, I apologize.
jfk
Ronald Reagan was nicknamed "Dutch".
JFK
No
As of June 2014, no U.S. President was nicknamed "Big Bill." William Howard Taft was nicknamed "Big Chief" and "Big Lub."
JFK
JFK
The 8th US President, Martin Van Buren, was nicknamed Old Kinderhook. He was born in Kinderhook NY.
Grover Cleveland
Ronald Reagan
Zachary Taylor!
US President Franklin Delano Roosevelt was often referred to by his initials FDR.