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The primary factor that determines how much oxygen is actually bound to hemoglobin is the partial pressure of oxygen (pO2) in the hemoglobin solution.

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12y ago
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12y ago

Other factors affecting the O2 affinity of hemoglobin:

1. BPG (2,3-bisphosphoglycerate): lowers O2 affinity of hemoglobin.

2. Reduction in pH causes lower O2 affinity of hemoglobin.

3. Release (accumulation) of CO2 in respiring tissues lowers O2 affinity of hemoglobin.

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Q: What are the factors that affect hemoglobin's affinity for oxygen?
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Related questions

What is BPG where is it produced and how does it affect the hemoglobins ability to bind with oxygen?

Actually bpg lowers the affinity of hemoglobin for binding to oxygen . It helps unloading the oxygen content near the tissues that need it like muscles . Hope I helped !


Does a low pH decrease hemoglobins affinity for oxygen?

Yes. This an example of the Bohr effect. If pH is lower than normal (normal is 7.4), then hemoglobin does not bind oxygen as well. The higher the pH, the lower the H ion concentration, the lower the carbon dioxide level, and the GREATER affinity hemoglobin has for oxygen. The binding of oxygen to hemoglobin in the lungs is not affected by changing the pH.


How do high-altitude locations affect breathing rate?

The amount of oxygen is same. The partial pressure of oxygen is lower at higher altitude. The reason why lungs must work harder is because oxygen is required in the body to supply hemoglobins in the blood. The affinity of hemoglobin to oxygen becomes lower as the partial pressure of oxygen decreases, creating a higher breathing rate in order to acquire more oxygen. Take an example of llama that lives up high in mountains. Their body is well adapted to it, such that their hemoglobin's affinity to oxygen is much higher than that of humans, and does not require extra work in order to acquire more oxygen.


Why is oxygen needed in blood?

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As it shifts to the right, it means that haemoglobin has a lesser affinity for oxygen


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