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Probably many things, but what I know of mainly is kicks. either from other horses or from himself, if flies are really bad, he could get really irritated and kick himself hard enough to leave marks. If that's the case, fly spray ought to do the trick. Get a vet out. For all you know, it could be life-threatening.

Answer 2:

Fist-sized lumps could be hives developed from skin irritations from insect bites or a plant that the horse is allergic too (or just plain Allergies to something), sarcoids (basically a dermatological tumour), a fungal infection like Phycomycosis, or Mastocytosis. You're best to have your local equine vet to check it out for you.

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Q: What can cause big fist size lumps under a horse's belly?
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