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Large volumes of blood loss can come from a variety of causes including colon infections, colon polyps and cancers, inflammatory bowel disease (ulcerative colitis and Crohn's disease), peptic ulcers or esopahgeal erosions.

Rapid bloos loss usually implies a blood vessel has been breached, usually by a tumor or ulcer or due to the formation of a direct connection (a fistula).

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Q: What causes a person to lose over a gallon of blood rectally?
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