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Q: What changes occur with the T cell when it binds to an antigen?
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What changes occur to a carrier protein once it binds to its target molecules?

the carrier protein changes shape to release the molecule inside of a cell


What occurs if a t cell binds to an antigen and the t cell does not receive a costimulatory signal?

The T cell enters a state of anergy


What occurs if a T cell binds to an antigen and the T cell does not receive a co-stimulatory signal?

The T cell enters a state of anergy. In this case, the T cell becomes tolerant to that antigen and is unable to divide or to secrete cytokines. This state of unresponsiveness to antigen is called anergy.


What must occur for a message to be sent from outside of the cell to the inside of a cell?

A signaling molecule binds with a membrane protein


What must occur for a message to be sent from the outside of the cell to the inside of cell?

A signaling molecule binds with a membrane protein


When an antigen binds to a Class 1 MHC molecule it stimulates what cell?

Class I MHC molecules present antigens to cytotoxic T-cells (which are CD3+CD8+).


Is T cell activation antigen specific?

Yes. The first signal that a T cell receives from an antigen presenting cell (dendritic cell) is MHC presenting an antigen (foreign peptide). This gives the T cell specificity to this antigen.


What must occur for a message to be sent from the outside of the cell of the to the inside?

A signaling molecule binds with a membrane protein


What must occur for a message to be sent from the outside of the cells to inside the cell?

A signaling molecule binds with a membrane protein


What must occur for a message to be sent outside a cell to the inside?

A signaling molecule binds with a membrane protein. ~apex


May occur in the cell shape of some unicellular organisms as life functions are carried out?

Changes may occur in the cell shape


What is the clonal selection theory as it applies to B cells?

1. An antigen presenting cell presents antigen on Class II MHC to a Helper T cell activating it 2. At the same time a B cell that has taken up and degraded the same pathogen displays antigen on its class II 3. The activated helper T cell binds to the B cell releasing cytokines and activating it 4. The activated B cell proliferates and differentiates into: 1) memory B cells 2) antibody-secreting plasma cells that produce antibodies specific for the pathogen