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Chemicals called neurotransmitters move across the synaptic gap by diffusion and carry a neural signal across to the receiving neuron. But the 'bubbles' (vesicles) which contained the neurotransmitter chemicals do NOT themselves cross the synaptic gap, they just release the neurotransmitters into the synaptic gap. (The neurotransmitters move across the synapse, the vesicles do not.)

The vesicles release their contents of neurotransmitters into the synaptic gap by a process called exocytosis, in which the neural impulse which reaches the terminal button of the presynaptic neuron causes voltage-gated calcium ion pores to open, allowing an influx of calcium ions, which leads to the fusing of the vesicles to the cell membrane, which amounts to the vesicles 'turning themselves inside out' as the membrane of the vesicle merges with the cell membrane, which expels the neurotransmitters into the synaptic gap.

The neurotransmitters flow across the synapse to bind with the postsynaptic neuron, potentially triggering neuron excitation (firing) or inhibition (preventing firing).

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Q: What do the bubbles of chemical crossing the synapse do?
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