What drugs that are monoamine oxidase inhibitors?

MAO is the enzyme involved in the metabolism of Dopamine and metanephrines. Deficiency or excess of this enzyme/activity was linked with depression, anxiety, bulimia, Parkinson. MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. There are two isoforms of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially deaminates serotonin, melatonin, epinephrine, and norepinephrine. MAO-B preferentially deaminates phenylethylamine and trace amines. Dopamine is equally deaminated by both types. Because of potentially lethal dietary and drug interactions, monoamine oxidase inhibitors have historically been reserved as a last line of treatment, used only when other classes of antidepressant drugs (for example selective serotonin reuptake inhibitors and tricyclic antidepressants) have failed. Exemples of MAOI: Isocarboxazid (Marplan), Isoniazid (Laniazid, Nydrazid), Nialamide (Niamid), Phenelzine (Nardil, Nardelzine), Procarbazine, Hydracarbazine<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />