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Acetycholine esterase. It breaks down Ach in the skeletal muscle endplate.

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Q: What enzyme has to be present for acetylcholine to be broken down so that the muscle fiber can relax?
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What terminates a muscle contraction?

"A muscle cell remains contracted until the release of acetylcholine stops and an enzyme produced at the axon terminal destroys any remaining acetylcholine."


What is acetylcholinesterace?

Acetylcholinesterase, also known as AChE, is an enzyme which is critical to the function of animals from ants to elephants. This enzyme's sole responsibility is to break down the neurotransmitter acetylcholine. Acetylcholine sends messages between nerves, signaling muscle contractions. If the neurotransmitter was not broken down after it had served its function, the muscle involved would not be able to relax, and this could create spasms, paralysis, and other problems.


What prevents acetylcholine from accumulating in the neuromuscular junction?

The presence of an enzyme called acetylcholinesterasethat degrades acetylcholine is what prevents an accumulation of the neurotransmitter and sustained muscle contraction. Acetylcholinesterase is an enzyme that can be found within the neuromuscular junction. Thus, when a nerve impulse causes the release of acetylcholine at the neuromuscular junction, there is a critical time in which the neurotransmitter can bind to receptors on the muscle before it is degraded.


What chemical stimulates muscle contraction?

acetylcholine (ACh)


What type of excitatory neurotransmitter is secreted by motor neurons innervating skeletal muscle?

Acetylcholine is the excitatory neurotransmitter released by neurons innervating skeletal muscles. Acetylcholine release stimulates muscle contraction by acting at the nicotinic-acetylcholine receptor on the surface of the muscle cell.


What is released to muscle cell receptors to trigger muscle contractions?

Acetylcholine


What is the neurotransmitter of alpha-motor neuron?

Alpha-Motor neurons release the neurotransmitter acetylcholine at a synapse called the neuromuscular junction. When the acetylcholine binds to acetylcholine receptors on the muscle fiber, an action potential is propagated along the muscle fiber in both directions.


What is the chemical transmitter released at the neuromuscular junction?

The neurotransmitter acetylcholine is released into the synaptic cleft to bind with receptors on muscle cells. Upon binding, the muscle cells contract.


Is acetylcholine stimulatory to cardiac muscle?

False


Why does acetylcholine causes vaso-dilation?

In some muscle tissue acetylcholine causes vaso-dilation, but not all. Norepinephrine is the opposite competor/effector of acetylcholine. Acetylcholine is present in all preganglionic fibers, both parasympathetic and sympathetic. Acetylcholine is present in postganglionic parasympatic fibers, where norepinephrine is present in the postganglionic sympathetic fibers. In some tissues acetylcholine causes constriction. Can also reduce heart rate vi the vagus nerve. Acetylcholine is the only neurotransmitter used in the somatic nervous system! Acetylcholine can effect vasodilation by several mechanisms, including activation of endothelial nitric oxide (NO) synthase and prostaglandin (PG) production. In human skin, exogenous Acetylcholine increases both skin blood flow and bioavailable NO levels, but the relative increase is much greater in skin blood flow than NO. So this may lead us to speculate that acetylcholine may dilate cutaneous blood vessels through PGs, as well as NO. In some muscle tissue acetylcholine causes vaso-dilation, but not all. Norepinephrine is the opposite competor/effector of acetylcholine. Acetylcholine is present in all preganglionic fibers, both parasympathetic and sympathetic. Acetylcholine is present in postganglionic parasympatic fibers, where norepinephrine is present in the postganglionic sympathetic fibers. In some tissues acetylcholine causes constriction. Can also reduce heart rate vi the vagus nerve. Acetylcholine is the only neurotransmitter used in the somatic nervous system! Acetylcholine can effect vasodilation by several mechanisms, including activation of endothelial nitric oxide (NO) synthase and prostaglandin (PG) production. In human skin, exogenous Acetylcholine increases both skin blood flow and bioavailable NO levels, but the relative increase is much greater in skin blood flow than NO. So this may lead us to speculate that acetylcholine may dilate cutaneous blood vessels through PGs, as well as NO.


What neurotransmitter stimulates skeletal muscle contractions?

Acetylcholine


What is the substance that halts stimulation of muscle tissue?

Acetylcholine