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Depends on why it is missing. If it is just a bad plug or plug wire, the worse that can happen is a ruined O2 sensor or a ruined catalytic converter. Unburnt fuel entering the exhaust can damage both. If the miss if from a burnt valve same scenario. If the miss is because of a blown head gasket or cracked head then the engine can suffer severe damage. If you are loosing coolant with no apparent leak, suspect a blown head gasket. If you oil level is above full, ditto. If your exhaust smells sweet, ditto. Air bubbles coming from the radiator, ditto. At worst case you are only running on 5 cylinders. Aside from using a lot more gas, it probably won't do any great damage unless you are pulling trailers or driving up hills. You will need it fixed to pass a smog inspection.

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Q: What happens if you ignore a bad cyl 6 misfire codes PO316 and P0306 How long can I let this go before getting fixed and what's the worst case scenario?
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