0
If there is a mutation in the 5' UTR no change in the protein function and abundance will happen.
Wiki User
∙ 10y ago
Add your answer:
Earn +20 pts
What is role of maskin protein?
Maskin protein prevents eukaryotic mRNAs from being recruited to the ribosome prior to egg fertilization. In other words, maskin halts translation of certain mRNA until after fertilization. In the 3' end of the mRNA there is an Untranslated Region (UTR) (often a rich A region) that does not code for amino acids of the protein. Instead regions of the UTR are binding sites for Cytoplasmic Poly A Element-Binding Protein (CPEB), which binds to maskin. (Other translation inhibitors have similar mechanisms.) This interaction acts to prevent assembly of translation of the mRNA initiation complex until after fertilization. Upon fertilization, phosphorylation of CPEB causes it to undergo a conformational alteration and release from the UTR. Translation can then proceed. Poly(A) binding protein (PBAP) is able to bind to the now open A-rich UTR. PBAP binds to the initiation factor eIF-4G, which is bound to eIF-4E, another initiation factor bound to the 5' cap on the 5' end of mRNA. This binding forms the characteristic loop structure of eukaryotic protein synthesis. Sources: Karp, Gerald C. Cell and Molecular Biology: Concepts and Experiments. edition 5 See the related link for further information.
What is mRNA base sequence for ATT?
The DNA segment 3' ATT 5' would be transcribed to the mRNA sequence 5' UAA 3'.
What is the function of a 5' cap in DNA transcription and translation?
The 5' cap attached to the mRNA ensures the mRNA's stability while it undergoes translation.
Why does not prokaryotic mRNA have 5' cap 3' tail?
No
What type of RNA is formed during transcription?
In Translation, rRNA, tRNA, and mRNA are used. The mRNA strand of codons (3 nucleotide bases) enters the ribosome where the rRNA will "read it" (it is made up of rRNA). tRNAs are floating in the cell carrying the anticodon's specified amino acid. When the rRNA "sees" which codon is on the mRNA strand, the tRNA's anticodon (complementary nucleotide bases) binds to the A site in the ribosome to start creating the polypeptide chain.
What is role of maskin protein?
Maskin protein prevents eukaryotic mRNAs from being recruited to the ribosome prior to egg fertilization. In other words, maskin halts translation of certain mRNA until after fertilization. In the 3' end of the mRNA there is an Untranslated Region (UTR) (often a rich A region) that does not code for amino acids of the protein. Instead regions of the UTR are binding sites for Cytoplasmic Poly A Element-Binding Protein (CPEB), which binds to maskin. (Other translation inhibitors have similar mechanisms.) This interaction acts to prevent assembly of translation of the mRNA initiation complex until after fertilization. Upon fertilization, phosphorylation of CPEB causes it to undergo a conformational alteration and release from the UTR. Translation can then proceed. Poly(A) binding protein (PBAP) is able to bind to the now open A-rich UTR. PBAP binds to the initiation factor eIF-4G, which is bound to eIF-4E, another initiation factor bound to the 5' cap on the 5' end of mRNA. This binding forms the characteristic loop structure of eukaryotic protein synthesis. Sources: Karp, Gerald C. Cell and Molecular Biology: Concepts and Experiments. edition 5 See the related link for further information.
The 5' cap of mRNA is important for what?
Protecting the mRNA while it travels from the nucleus to the ribosome.
What is mRNA base sequence for ATT?
The DNA segment 3' ATT 5' would be transcribed to the mRNA sequence 5' UAA 3'.
What is the function of a 5' cap in DNA transcription and translation?
The 5' cap attached to the mRNA ensures the mRNA's stability while it undergoes translation.
Why does not prokaryotic mRNA have 5' cap 3' tail?
No
How is mRNA read in translation?
in the 5' to 3' direction
What does the 5' junction in mRNA stand for?
Messenger ribonucleic acid
What is the purpose of the 5' cap and the 3' poly A tail?
5' cap helps protect mRNA from degradation by hydrolytic enzymes and after mRNA reaches the cytoplasm, the 5' cap functions as part of an "attach here" sign for ribosomes. The poly-A-tail inhibits degradation of RNA and helps ribosomes attach and facilitates export of mRNA from the nucleus.
What is the sequence of the peptide based on the mRNA sequence 5'uuuuccuauugucuu3'?
phenylalanine
What does DNA translation start with?
The small subunit of the ribosome binds to a site "upstream" (on the 5' side) of the start of the message.It proceeds downstream (5' -> 3') until it encounters the start codon AUG. (The region between the mRNA cap and the AUG is known as the 5'-untranslated region [5'-UTR].)Here it is joined by the large subunit and a special initiator tRNA.The initiator tRNA binds to the P site (shown in pink) on the ribosome.In eukaryotes, initiator tRNA carries methionine (Met). (Bacteria use a modified methionine designated fMet.)
What are the major steps of mRNA transcription?
mRNA is produced based on the DNA code. If the original (correct) sequence is AGC, then the correct mRNA sequence should be UCG.However, the mutated DNA sequence (ATC) now codes for the mRNA sequence UAG. So, the incorrect DNA sequence is spread through to create an incorrect mRNA sequence.
What is the corresponding mrna section of 3'-tgt-ggg-gtt-att-5'?
The mRNA sequence which is complementary to the DNA sequence 5' - GAC ATG GAA - 3' is:3' - CUG UAC CUU - 5'
