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Hepatic microsomal enzyme induction or in other words the stimulation of the microsomal enzymes of the liver occur as a result of administration of certain drugs such as Phenobarbitone, Phenytoin or Carbamezapine. These drugs stimulate this enzyme system in the liver and accelerate the metabolism of other substances such as Coumarin anticoagulants that are administered to a person to prevent clotting tendency. In that case, the physician would consider increasing the dose of the Coumarin anticoagulants to achieve an optimum effect since the accelerated metabolism of these drugs will not produce the desired effect.
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∙ 13y ago
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What is hepatic microsoal induction give examples?
Hepatic microsomal induction, you might mean, is as it is, induction of hepatic microsomal enzymes. These microsomal enzymes are found in the liver and are responsible for the metabolism of drugs that we take in. There are some drugs though, that can increase the activity of these enzymes. Some examples are: Dicoumarol Disulfiram Isoniazid Cimetidine Chloramphenicol Sulfonamides If these drugs are taken in along with another, the metabolism of the other drug will be decreased, resulting in an increased half life.
What is Microsomal oxidation?
Microsomal oxidation is the type of biological oxidation catalyzed by special cytochrome P-450 (CYP) enzyme group (superfamily) which takes place predominantly in hepatic microsomes, which are fragments of liver cells endoplasmatic membranes.
An antimicroial that inhibits hepatic P450 microsomal enzymes?
Sulfonamide
What has the author Rachael Ing written?
Rachael Ing has written: 'Enzymology and induction of hepatic cytochrome P450s in the guinea pig'
What does the liver do when detoxification?
The liver uses enzymes to alter chemicals and convert them fro fat-soluble forms to water-soluble forms which are more readily excreted through the urine and fecal matter.Follow the related link below (Liver Detox - Liver Cleanse) for more information.
What are Three ways to control enzyme?
One way to control an enzyme is through post-translational modification such as phosphorylation or glycosylation. Other ways to control enzymes are through enzyme induction, inhibition, or by compartmentalizing the metabolic pathways.
Give one example of a drug interraction resulting fron enzyme inhibition and enzyme induction?
if there is any inborn errors with enzyme B means, there will be a malfunctioning... so here the enzyme can not convert comp 1 to comp 2... so automatically enzyme C wont be having any function!!
What are the advantages and disadvantages of barbiturates?
in humans barbiturates are used for the induction of anaesthesia because drug is very very non-polar in nature and can easily produce anaesthesia while the disadvantage is that ; it produces enzyme induction that can lead to drug tolerance.
What has the author Yu -kuang Ch en written?
Yu -kuang Ch en has written: 'Urease induction in barley leaves by foliar application of urea' -- subject(s): Barley, Enzyme induction, Growth, Fertilizers, Urease
What causes high levels of Microsomal AB?
I just received my test results on Microsomal AB the results were 203 what does this mean You may have Hashimoto's but I would check with you doctor if you haven't discussed the results with him/her already.
What veins drain the liver?
hepatic
Is there a difference between enzyme inhibition and enzyme suppression?
enzyme induction: Many of the enzymes involved in drug metabolism may be up-regulated by exposure to drugs and environmental chemicals leading to increased rates of metabolism. This phenomenon is known as enzyme induction Enzyme inhibition: Inhibiting the activity of enzymes(generally done by heating, changing Ph, reaction with different chemicals.)
