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What is protein localization?

Updated: 10/17/2022
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8y ago

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Protein localization is the process of figuring out where in a cell a particular protein is located.

If you want some insight into the function of a protein its always a good idea to know where it is in your cell and when i.e. the protein's location. Most proteins have N-terminal sequences that, in one way or another, tells the cell where to send the proteins its just made. For example, the protein may be directed towards the cell membrane ready for secretion. A common protein localization technique is to fuse a protein with a florescent amino acid sequence which the protein then drags about with it giving away its location to a florescent sensitive microscope. This can even be done in real time.

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Protein localization is the process of figuring out where in a cell a particular protein is located. If you want some insight into the function of a protein its always a good idea to know where it is in your cell and when i.e. the protein's location. Most proteins have N-terminal sequences that, in one way or another, tells the cell where to send the proteins its just made. For example, the protein may be directed towards the cell membrane ready for secretion. A common protein localization technique is to fuse a protein with a florescent amino acid sequence which the protein then drags about with it giving away its location to a florescent sensitive microscope. This can even be done in real time.


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