A platelet plug is formed through the following processes in order to literally plug a hole in the wall of the vascular lumen:
False. This happens when a clot is formed
a blockage
exposed to a rough surface
Primary homeostasis includes vascular constriction and platelet plug( aggregate plug) formation in response to bleeding. Mainly vessel function and platelet function are mainly concerned in primary homeostasis.
a clot is formed when a platelet breaks and causes othe platelets to pile up
serotonin
The stimulus for a platelet formation is bleeding where the body automatically detects if there is a presence of bleeding inside or outside the body.
Vasoconstriction, platelet plug formation and clotting of blood.
erythrocytes
Platelets are blood cells that help stop bleeding. When we cut ourselves we have broken a blood vessel and the blood leaks out. In order to plug up the holes where the blood is leaking from the platelets start to stick to the opening of the damaged blood vessels. As the platelets stick to the opening of the damaged vessel they attract more platelets, fibers and other blood cells to help form a plug to seal the broken blood vessel. When the platelet plug is completely formed the wound stops bleeding. We call our platelet plugs scabs.
Here are the three processes for platelet plug formation:1. Platelet adhesionThe platelets will adhere to the collage fibres exposed in a damaged blood vessel. This occurs when the glycoprotein 1b (GPb1) receptors of the platelets interact with the von Willebrand factor (vWb) synthesised by endothelium.2. Platelet activationThis process is initiated by the collagen fibres, the adenosine diphosphate (ADP), and thrombin. It causes the platelets to synthesise thromboxane A2 (TXA2) and to releasethe contents of their dense granules which contain ADP and 5-hydroxytryptamine.3. Platelet aggregationThe released mediators will cause the platelets to change from a discoid shape to a sphere with spiny projections. This new shape will increase the chances of the platelets making contact with other platelets. The platelets will then aggregate with fibrinogen and vWf as connecting agents via their glycoprotein IIb/IIIa receptors. ADP and TXA2 act as chemotactic factors to attract more platelets and the positive feedback loop created forms the platelet plug which temporarily seals the break in the damaged blood vessel.
Hemostasis occurs in a sequence: 1. Vasoconstriction 2. Formation of platelet plug 3. Formaion of clot Bleeding time is the time from the onset of bleeding till the stoppage of bleeding i.e. temporary hemoststic plug formation (platelet plug). Clotting time is the time from the onset of bleeding till the clot formation (i.e. definitive hemostatic plug). Hence, clotting time is longer then bleeding time.