exposed to a rough surface
serotonin
Platelets are blood cells that help stop bleeding. When we cut ourselves we have broken a blood vessel and the blood leaks out. In order to plug up the holes where the blood is leaking from the platelets start to stick to the opening of the damaged blood vessels. As the platelets stick to the opening of the damaged vessel they attract more platelets, fibers and other blood cells to help form a plug to seal the broken blood vessel. When the platelet plug is completely formed the wound stops bleeding. We call our platelet plugs scabs.
Here are the three processes for platelet plug formation:1. Platelet adhesionThe platelets will adhere to the collage fibres exposed in a damaged blood vessel. This occurs when the glycoprotein 1b (GPb1) receptors of the platelets interact with the von Willebrand factor (vWb) synthesised by endothelium.2. Platelet activationThis process is initiated by the collagen fibres, the adenosine diphosphate (ADP), and thrombin. It causes the platelets to synthesise thromboxane A2 (TXA2) and to releasethe contents of their dense granules which contain ADP and 5-hydroxytryptamine.3. Platelet aggregationThe released mediators will cause the platelets to change from a discoid shape to a sphere with spiny projections. This new shape will increase the chances of the platelets making contact with other platelets. The platelets will then aggregate with fibrinogen and vWf as connecting agents via their glycoprotein IIb/IIIa receptors. ADP and TXA2 act as chemotactic factors to attract more platelets and the positive feedback loop created forms the platelet plug which temporarily seals the break in the damaged blood vessel.
Fibrin threads interlace the platelet plug to come up with a clot, which traps red blood cells.
First the platelet phase occurs in which the endothelial cells become sticky as to where the injury occurred then platelets come in releasing a hormone seratonin to make the vessels go into spasm and then the platelets form a platelet plug after that the coagulation phase occurs as the fibrinogen turns into fibrin to make strands in order to stop the continous bleeding
False. This happens when a clot is formed
Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium (lining of the vessel). Exposure of the blood to proteins such as tissue factor initiates changes to blood platelets and the plasma protein fibrinogen, a clotting factor. Platelets immediately form a plug at the site of injury; this is called primary hemostasis. Secondary hemostasis occurs simultaneously: Proteins in the blood plasma, called coagulation factors or clotting factors, respond in a complex cascade to form fibrin strands, which strengthen the platelet plug
The stimulus for a platelet formation is bleeding where the body automatically detects if there is a presence of bleeding inside or outside the body.
Platelets are irregularly-shaped, colorless forms that are available in blood. Their sticky surface lets them to form clots to stop bleeding. When bleeding from a wound starts, the platelets accumulate at the wound and try to block the blood stream. The calcium, vitamin K, & a protein called fibrinogen help the platelets to form coagulation. A clot starts to form when the blood is in contact with air. The platelets sense the existence of air and start to separate. They respond with the fibrinogen to start forming fibrin, which looks like fiber. The fibrin then starts to structure a web-like work that traps the platelets inside it. This cross section of platelets solidifies as it dries, shaping a coagulation, or "scab."
Platelets form to help control the blood loss.
when the endothelium of blood vessels get ruptured due to any reason(such as trauma) revealing the subendothelial layer, the platelets swing into action quickly to minimize blood loss so as to maintain homeostasis.first of all they release certain biomolecules such as serotonin so as to cause vasoconstriction.simultaneously they on coming in contact with certain proteins of the subendothelial layer release certain biomolecules that attract more and more platelets to the site of injury forming a plug so as to minimize the blood loss.this aggregated form of platlrts is called platelet plug or sometimes called the white clot.this step is the primary one in initiating clotting of blood.
A platelet plug is formed through the following processes in order to literally plug a hole in the wall of the vascular lumen: