The Panama Canal is the shortest route.
Take I-65 SOUTH to NASHVILLE.
I-95 South
The shortest route between South America and Africa would have you leaving from the nation of Brazil. Brazil remained a Portuguese colony until 1808.
wormhole
about 17 hours the shortest
464 miles. I-70 West to I-57 South to I-55 South
I-95 south to Jacksonville I-75 south to Tampa
The road distance between the above places is 1950 miles . This is the distance when the shortest route is chosen. Traffic rules like ‘No Entries’ and ‘One Ways’ have not been considered when calculating this distance.
Take I-65 SOUTH to Nashville bypassing Indianapolis via I-465 SOUTH.
It appears that the Shortest route I can find is from Jacksonville Beach, FL to San Diego, CA, at a distance of 2,109 miles according to Google Maps.
South Canal!